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Gradual dose escalation improves gastrointestinal tolerability.78 Acute pancreatitis is a rare but documented adverse event associated with exenatide use, as reported in the FDA Adverse Event Reporting System and observational studies.79 Current guidelines from the American Association of Clinical Endocrinologists recommend cautious use of GLP-1RAs in T2DM patients with a history of pancreatitis80 (See Figures 2 and 3)

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They affect hormones involved in hunger, digestion, insulin release, and blood sugar levels